Postdoctoral Training Fellow - Mechanisms and Regulation of pre-mRNA Splicing
The Institute of Cancer Research
United Kingdom
Research and Science
Job posted on January 11, 2025
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Job Description:
Key Information
Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has completed their viva but has not yet been awarded their PhD, the starting salary will be £35,844, pre-PhD level. Progression to the full PDTF scale will commence once confirmation of PhD award is received. Award must be provided within 6 months of start date.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here .
Duration of Contract: Fixed Term for 36 months
Hours per week: 35 hours per week (Full Time)
Closing Date: Saturday 15 February 2025
Job Details
Under the leadership of Professor Vlad Pena, we are seeking to appoint a Postdoctoral Training Fellow with a strong interest in the structural biology of RNA-protein complexes.
The primary objective of this project is to elucidate how RNA splicing is regulated by a specific set of chromatin factors. The successful candidate will focus on reconstituting spliceosomes involved in this process and determining their structures using cryo-electron microscopy (cryo-EM). Comprehensive training in specialized techniques will be provided.
Our laboratory offers regular access to cutting-edge structural biology facilities, including recombinant protein expression, purification systems, mammalian cell bioreactors, advanced electron microscopy (Glacios and Titan Krios), high-performance GPU computing clusters, mass spectrometry, and both preparative and analytical biochemistry tools. More detailed information about our research can be found on our webpage .
For general information on Post Doc's at The ICR can be found here .
Key Requirements
T he successful candidate must have a PhD (or equivalent) in structural biology and demonstrate strong expertise in the biochemistry of macromolecular complexes. While experience in RNA biology, the structural study of RNA-protein complexes, and cryo-EM is advantageous, we encourage applications from all talented scientists with a passion for this field.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years
Department/Directorate Information
The Division of Structural Biology is located at the ICR site in the picturesque Chelsea district of London, offering a vibrant scientific and cultural atmosphere and excellent opportunities for both personal and professional growth.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof Vlad Pena at [email protected]
About The Institute Of Cancer Research
Why work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits .
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here .
At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.
Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.
APPLY NOW
Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has completed their viva but has not yet been awarded their PhD, the starting salary will be £35,844, pre-PhD level. Progression to the full PDTF scale will commence once confirmation of PhD award is received. Award must be provided within 6 months of start date.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here .
Duration of Contract: Fixed Term for 36 months
Hours per week: 35 hours per week (Full Time)
Closing Date: Saturday 15 February 2025
Job Details
Under the leadership of Professor Vlad Pena, we are seeking to appoint a Postdoctoral Training Fellow with a strong interest in the structural biology of RNA-protein complexes.
The primary objective of this project is to elucidate how RNA splicing is regulated by a specific set of chromatin factors. The successful candidate will focus on reconstituting spliceosomes involved in this process and determining their structures using cryo-electron microscopy (cryo-EM). Comprehensive training in specialized techniques will be provided.
Our laboratory offers regular access to cutting-edge structural biology facilities, including recombinant protein expression, purification systems, mammalian cell bioreactors, advanced electron microscopy (Glacios and Titan Krios), high-performance GPU computing clusters, mass spectrometry, and both preparative and analytical biochemistry tools. More detailed information about our research can be found on our webpage .
For general information on Post Doc's at The ICR can be found here .
Key Requirements
T he successful candidate must have a PhD (or equivalent) in structural biology and demonstrate strong expertise in the biochemistry of macromolecular complexes. While experience in RNA biology, the structural study of RNA-protein complexes, and cryo-EM is advantageous, we encourage applications from all talented scientists with a passion for this field.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years
Department/Directorate Information
The Division of Structural Biology is located at the ICR site in the picturesque Chelsea district of London, offering a vibrant scientific and cultural atmosphere and excellent opportunities for both personal and professional growth.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof Vlad Pena at [email protected]
About The Institute Of Cancer Research
Why work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits .
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here .
At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.
Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.